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Hydroxyurea significantly improves the frequency of sickle cell crisis, but it has a long list of adverse effects. But if the dose is monitored properly and complete blood count of patient is done on regular basis, than some of the adverse effects can be easily identified and managed accordingly.

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The lower cost associated with hydroxyurea therapy stems from the compound's ability to prevent or reduce the occurrence of pain crises and serious respiratory complications that require blood transfusions and other treatments, the researchers say.

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Hydroxyurea treatment was also associated with a reduction in the number of dense red cells that have a high propensity for polymer formation.

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Sickle cell disease: current therapeutic approaches.

Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series of 145 patients.

Infections: Infections are managed using antibiotic prophylaxis and early immunization for Pneumococcus and Meningococcus infections.

Findings from a multicenter clinical trial show that daily administration of the drug hydroxyurea reduced by about 50% the frequency of painful episodes and hospital visits for those episodes.

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Controlled randomised Double Blind study for the Comparison of the Treatment of Patients with Essential Hypertension with Homoeopathic and Pharmacologically Effective Drugs.

Sustained complete molecular remissions after treatment with imatinib-mesylate in patients with failure after allogeneic stem cell transplantation for chronic myelogenous leukemia: results of a prospective phase II open-label multicenter study.

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In summary, our results strongly suggest that HbF induction by hydroxyurea is mediated by the NO-dependent activation of sGC.

They should also determine when to begin the use of hydroxyurea to treat or prevent complications of sickle cell disease and how long to continue its use.

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The presently available treatment options in PV were discussed and recommendations for the clinical management were given.

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These guidelines were developed by an expert panel composed of health care professionals with expertise in family medicine, general internal medicine, adult and pediatric hematology, psychiatry, transfusion medicine, obstetrics and gynecology, emergency department nursing, and evidence-based medicine.

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The association of hydroxyurea with the development of acute pulmonary reactions consisting of diffuse pulmonary infiltrates, fever, and dyspnea has been reported.

Both men and women taking this medicine should use birth control to prevent pregnancy.

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The FDA permits veterinarians to prescribe hydroxyurea as an extra-label drug.

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