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Dopamine receptor agonists (also called dopamine agonists) mimic the effects of dopamine by acting on dopamine receptors in the brain.

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The condition also occurs when drugs to treat Parkinson's disease are stopped.

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After completing the study, a rater blinded to the treatment reassessed the tremor rating scales based on video recordings.

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Mirapex), which was already approved throughout the European Union in April 2006 for this second indication.

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Although mean values remained within normal reference ranges throughout the study, supine systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate for subjects treated with pramipexole generally increased during the rapid up-titration phase, by 10 mmHg, 7 mmHg, and 10 bpm higher than placebo, respectively.

Elimination Urinary excretion is the major route of pramipexole elimination, with 90% of a pramipexole dose recovered in urine, almost all as unchanged drug.

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Confusion and hallucinations imply a bad prognosis with high mortality within 1-2 years.

Side effects can include constipation, sedation, seizures (rare) and some problems thinking.

In one controlled study, pramipexole was shown to be efficacious in the treatment of unipolar depression.

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Of 234 patients who were evaluable, 196 had been treated for two years and 29 were judged to have developed clinical abnormalities that were considered meaningful (19 patients in each treatment arm had received treatment for less than two years).

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Common stroboscopy findings in Parkinson disease include true vocal fold atrophy or other evidence of glottal incompetence, including a chasing wave or a shorter closed phase.

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Null hypothesis: No difference between pramipexole and placebo in RLSRS total score from baseline and no difference in the CGI-I responder rates at the end of the 6 weeks double-blind treatment.

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If they are iron deficient, they should start treatment with iron supplements.

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